RESEARCH & PUBLICATIONS

 
 

CLINICAL STUDIES

Measuring Disease Activity with DARC.

Glaucoma

PHASE I

Real-time imaging of single neuronal cell apoptosis in patients with glaucoma.

Cordeiro et al., 2017

Glaucoma / amd / optic neuritis

PHASE II

A Phase II, open-label, non-randomised, single site, clinical trial of ANX776 in patients.

Trial completed, analysis underway.

 
 

EXPERIMENTAL STUDIES

Measuring Disease Activity and
Treatment Efficacy with DARC.

GLAUCOMA / OPTIC NEUROPATHY

Real time imaging of single nerve cell apoptosis in retinal neurodegeneration. Proceedings of the National Academy of Science.

Cordeiro et al., 2004

GLAUCOMA

Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure (IOP) and IOP-induced effects on extracellular matrix.

Guo et al., 2005


 

GLAUCOMA

Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo.

Guo et al., 2006

GLAUCOMA

Assessment of rat and mouse RGC apoptosis imaging in vivo with different scanning laser ophthalmoscopes.

Maass et al., 2007


 

ALZHEIMER’S / GLAUCOMA

Targeting Amyloid-ß in glaucoma treatment.

Guo et al., 2007

DIABETES / TRANSGENIC

Diabetic Retinal Neurodegeneration: In vivo Imaging of Retinal Ganglion Cell Apoptosis.

Borrie et al., 2008


 

RETINAL DEGENERATION

Real-time in-vivo imaging of retinal cell apoptosis after laser exposure.

Schmitz-Valckenberg et al., 2008

RETINAL DEGENERATION

In-vivo imaging of retinal cell apoptosis following acute light exposure.

Schmitz-Valckenberg et al., 2009


 

GLAUCOMA / ALZHEIMER’S

Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo.

Cordeiro et al., 2010

RETINAL DEGENERATION

Imaging Dry AMD.

Normando et al., 2013


 

GLAUCOMA

Unexpected Low Dose Toxicity of the Universal Solvent, DMSO.

Galvao et al., 2014

ALZHEIMER’S / GLAUCOMA

Effect of the Aβ aggregation modulator MRZ-99030 on retinal damage in an animal model of glaucoma.

Salt et al., 2014


 

OPTIC NEUROPATHY

Direct optic nerve sheath (DONS) application of Schwann cells prolongs retinal ganglion cell survival in vivo.

Guo et al., 2014

OPTIC NEUROPATHY

Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.

Galvao et al., 2015


 

PARKINSON’S

The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson's disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain.

Normando et al., 2016

ALZHEIMER’S / GLAUCOMA

Non-amyloidogenic effects of α2-adrenergic agonists: implications for brimonidine-mediated neuroprotection.

Nizari et al., 2016


 

GLAUCOMA

Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension.

Davis et al., 2017